Enantioselective Organocatalytic Aza-Michael Additions of Phthalimide Derivatives to α,β-Unsaturated Aldehydes |
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| Authors: | Shijun Ma Ming Liu Yaodong Huang Yongmei Wang |
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| Institution: | 1. Department of Chemistry, The Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
2. Department of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China |
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| Abstract: | Phthalimide derivatives as nitrogen nucleophiles with α,β‐unsaturated aldehydes for asymmetric aza‐Michael additions have been reported. The reactions proceed smoothly to afford corresponding Michael adducts in good yields (up to 98%) and enantioselectivities (up to 95% ee). |
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| Keywords: | phthalimide derivatives α β-unsaturated aldehydes aza-Michael addition enantioselectivity |
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