Diastereoselective dearomatization of resorcinols directed by a lactic acid tether: unprecedented enantioselective access to p-quinols |
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Authors: | Mejorado Lupe H Hoarau Christophe Pettus Thomas R R |
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Affiliation: | Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106-9150, USA. |
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Abstract: | An operationally simple oxidative dearomatization of resorcinol derivatives is reported that employs an inexpensive chiral directing group. The method provides access to a variety of p-quinol derivatives in good yield and diastereoselectivity. A short reductive process affords 4-hydroxy-4-alkylcyclohexenone derivatives in excellent yields and enantiomeric excesses. |
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