Polychlorinated androstanes from the burrowing sponge Cliona nigricans |
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Authors: | Fattorusso Ernesto Taglialatela-Scafati Orazio Petrucci Francesca Bavestrello Giorgio Calcinai Barbara Cerrano Carlo Di Meglio Paola Ianaro Angela |
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Institution: | Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli "Federico II", Via D. Montesano 49, I-80131 Napoli, Italy. fattoru@unina.it |
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Abstract: | Two new steroidal derivatives, named clionastatins A and B, have been isolated from the burrowing sponge Cliona nigricans. These molecules are tri-and tetrachlorinated androstane derivatives, respectively, and they represent the first polyhalogenated steroids found in a natural organism, either marine or terrestrial, and the first examples of halogenated androstanes in nature. Both clionastatins proved to be potently cytotoxic. |
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