Sintokamides A to E, chlorinated peptides from the sponge Dysidea sp. that inhibit transactivation of the N-terminus of the androgen receptor in prostate cancer cells |
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| Authors: | Sadar Marianne D Williams David E Mawji Nasrin R Patrick Brian O Wikanta Thamrin Chasanah Ekowati Irianto Hari Eko Soest Rob Van Andersen Raymond J |
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| Affiliation: | Genome Sciences Centre, B.C. Cancer Agency, 600 West 10th Avenue, Vancouver, BC, Canada V5Z 4E6. |
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| Abstract: | ![]()
The new chlorinated peptides sintokamides A to E (1-5) have been isolated from specimens of the marine sponge Dysidea sp. collected in Indonesia. Their structures were elucidated by a combination of spectroscopic and single-crystal X-ray diffraction analyses. Sintokamide A (1) is an inhibitor of N-terminus transactivation of the androgen receptor in prostate cancer cells. |
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