新型2H-噻唑[3,2-b][1,2,4]三嗪-3,7-二酮的超声辅助一锅法合成及乙酰胆碱酯酶抑制活性研究

以取代苯甲醛、溴乙腈和6-苄基-3-硫代-3,4-二氢-1,2,4-三嗪-5(2H)-酮为起始原料,在超声辅助下,一锅合成了9个新型6-苄基-2-亚苄基-2H-噻唑3,2-b]1,2,4]三嗪-3,7-二酮类化合物,结构经_¹H NMR,_¹³C NMR和MS（ESI）表征并对其合成机理进行了初步研究。测试了目标化合物(4a~4i)的体外乙酰胆碱酯酶的抑制活性,其中4a和4d抑制活性最好,有进一步研究的价值。

One-pot Synthesis and Acetylcholinesterase Inhibitory Activities of Novel 2H-thiazole [3,2-b] [1,2,4] triazine-3,7-diones Under Ultrasonic Radiation

Nine novel 6-benzyl-2-benzylidene-2H-thiazole3,2-b]1,2,4]triazine-3,7-diones were synthesized by substituted benzaldehyde, bromoacetonitrile and 6-benzyl-3-thio-3,4-dihydro-1,2,4-triazine-5(2H)-one in one pot under the assistance of ultrasound. The structures were characterized by _¹H NMR, _¹³C NMR and MS (ESI). The synthesis mechanism was preliminarily studied. The acetylcholinesterase inhibitory activities of compounds (4a~4i) were tested. Compounds 4a and 4d have the best inhibitory activities, which are worthy of further studies.