The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12) expression is briefly up regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic injury期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12) expression is briefly up regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic injury

Authors:	Jason T Miller John H Bartley Hereward JC Wimborne Aisha L Walker David C Hess William D Hill and James E Carroll

Institution:	(1) Department of Neurology, Medical College of Georgia, 30912 Augusta, GA, USA;(2) Department of Pediatrics, Medical College of Georgia, 30912 Augusta, GA, USA;(3) Veteran's Affairs Medical Center, 1 Freedom Way, 30904 Augusta, GA, USA;(4) Department of Cellular Biology & Anatomy, Medical College of Georgia, 30912 Augusta, GA, USA

Abstract:	Background Stromal cell-derived factor 1 (SDF-1 or CXCL12) is chemotaxic for CXCR4 expressing bone marrow-derived cells. It functions in brain embryonic development and in response to ischemic injury in helping guide neuroblast migration and vasculogenesis. In experimental adult stroke models SDF-1 is expressed perivascularly in the injured region up to 30 days after the injury, suggesting it could be a therapeutic target for tissue repair strategies. We hypothesized that SDF-1 would be expressed in similar temporal and spatial patterns following hypoxic-ischemic (HI) injury in neonatal brain.

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