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Dibromomethane as one-carbon source in organic synthesis: total synthesis of (±)-canadensolide |
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| Authors: | Yung-Son Hon Cheng-Han Hsieh |
| Affiliation: | a Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi 62102, Taiwan, ROC b Institute of Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan, ROC |
| Abstract: | A diastereoselective total synthesis of (±)-canadensolide is described. The key step is to introduce the α-methylene group by the ozonolysis of mono-substituted alkenes followed by reaction with a preheated mixture of CH2Br2-Et2NH. |
| Keywords: | Canadensolide α-Methylene-γ-butyrolactones Bislactones α-Methylenation |
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