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Convergent synthesis of PAMAM dendrimers using click chemistry of azide-functionalized PAMAM dendrons |
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| Authors: | Jae Wook Lee Jung Hwan Kim Ji Hyeon Kim Sung-Ho Jin |
| Institution: | a Department of Chemistry, Dong-A University, Hadan-2-dong, Busan 604-714, Republic of Korea b Department of Chemical and Biochemical Engineering, Dongguk University, Seoul 100-715, Republic of Korea c Department of Chemistry Education and Center for Plastic Information System, Pusan National University, Busan 609-735, Republic of Korea |
| Abstract: | Azide-functionalized PAMAM dendrons containing an azidopropylamine focal point were synthesized by the divergent method and applied for the construction of symmetric PAMAM-like dendrimers containing 1,2,3-triazole rings as connectors via stitching with two different multi-terminal alkynes. The stitching method was based on the click chemistry protocol, i.e., the copper-catalyzed cycloaddition reaction between an alkyne and an azide. |
| Keywords: | Alkyne Azide Click chemistry PAMAM dendrimers 1 2 3-Triazoles |
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