Ten new antifouling briarane diterpenoids from the South China Sea gorgonian Junceella juncea |
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| Authors: | Shu-Hua Qi Si Zhang Zhi-Hui Xiao |
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| Affiliation: | a Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, The Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, People's Republic of China
b Hong Kong University of Science and Technology/Department Biology—CML/Clearwater Bay, KLN, Hong Kong, China |
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| Abstract: | Ten new antifouling briarane diterpenoids, juncins R-ZI (1-10) were isolated from the South China Sea gorgonian coral Junceella juncea. The structures of these new compounds were established by extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 1-10 all showed potent antifouling activities against the larval settlement of barnacle Balanus amphitrite at nontoxic concentrations with EC50 values of 0.004, 0.34, 2.65, 1.61, 3.77, 21.06, 0.004, 0.14, 1.47, and 0.51 μg mL−1. The structure-activity relationship was discussed. |
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| Keywords: | Junceella juncea Briarane diterpenoids Antifouling Structure-activity relationship |
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