alpha-Aminoallylation of aldehydes with ammonia: stereoselective synthesis of homoallylic primary amines |
| |
| Authors: | Sugiura Masaharu Hirano Keiichi Kobayashi Shu |
| |
| Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. |
| |
| Abstract: | Three-component reactions of aldehydes, ammonia, and allylboronates were found to provide homoallylic primary amines in high yields with high chemo- and stereoselectivities. A two-step, one-pot, stereoselective synthesis of an uncommon alpha-amino acid, alloisoleucine, was achieved utilizing this reaction. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
