Synthesis of Some Novel 2,6- Dimethoxyhydroquinone-3- mercaptoacetyl-peptide Conjugates as Potential Antitumor Agents

This paper reports an ongoing study of the use of short chain peptides as carriers of a potential antitumor agents: 2, 6 -dimethoxyhydroquinone -3 -mercaptoacetic acid (DMQ-MA). Three new peptide-DMQ-MA conjugates: DMQ-MA-arg-arg-ome, DMQ -MA- lys(cbz) -arg-ome,DMQ- MA-lys(cbz) -arg- arg- ome were synthesized by coupling protected amino acids in solution and the next conjugation was achieved by reacting with pentafluorophenyl ester of DMQ-MA in DMF, and further study on their ability to inhibit human pulmonary adenocarcinoma cell line (PC-9 cells) and oral epidermoid carcinoma cell line (KB) are investigating.