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Bromodimethylsulfonium bromide (BDMS)-catalyzed multicomponent synthesis of 3-aminoalkylated indoles |
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| Authors: | Deepak K. Yadav Vishnu P. Srivastava Lal Dhar S. Yadav |
| Affiliation: | a Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad 211 002, India b Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211 002, India |
| Abstract: | Bromodimethylsulfonium bromide (BDMS)-catalyzed three-component coupling reaction between indoles, aldehydes, and N-alkylanilines is reported to access substituted 3-aminoalkylated indoles at room temperature in high yields (82-96%) within 1.5-3.5 h. The salient features of this protocol are the simplicity of the procedure, the ready accessibility of the catalyst, its cost effectiveness, and higher yields in relatively short reaction times. |
| Keywords: | Bromodimethylsulfonium bromide (BDMS) 3-Substituted indoles Multicomponent reaction Catalytic process N-Alkylanilines |
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