An efficient and facile one-pot synthesis of propargylamines by three-component coupling of aldehydes, amines, and alkynes via C-H activation catalyzed by NiCl2 |
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Authors: | Subhasis Samai |
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Institution: | Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India |
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Abstract: | NiCl2 was found to be a highly efficient and effective catalyst for the one-pot three-component (A3) coupling of aldehydes, amines, and alkynes to produce propargylamines in nearly quantitative yields. Structurally divergent aldehydes, amines, and alkynes were converted into the corresponding propargylamines. No co-catalyst or activator is needed and water is the only byproduct of this novel protocol. |
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Keywords: | Three-component A3-coupling C-H bond activation NiCl2 Propargylamines Aldehydes Amines |
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