A double heteroatom Mitsunobu coupling with amino hydroxybenzoic acids on solid phase: a novel application of the Mitsunobu reaction to form dendron building blocks |
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| Authors: | Tzachi Shalit Amnon Albeck |
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| Affiliation: | a Department of Biological Chemistry, Ariel University Center of Samaria, Ariel 40700, Israel
b The Julius Spokojny Bioorganic Chemistry Laboratory, Department of Chemistry, Bar-Ilan University, Ramat Gan 52900, Israel |
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| Abstract: | A new highly efficient double heteroatom Mitsunobu coupling with amino hydroxybenzoic acids on solid phase is described. The synthetic routes reported in this work are general and applicable for the preparation of diverse building blocks, controlling protection, arm length, chirality, and peripheral functional groups. These novel units can form unusual dendritic architectures, which could be incorporated into specific complex structures, expanding the scope of dendrimer science. |
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| Keywords: | Dendron building block Heteroatom Mitsunobu coupling Azo compounds Phosphines |
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