| 纳米脂质体复合物-包封多酸化合物的合成,表征和生物活性研究 |
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| 引用本文： | 杨勇,王晓红,李斌,刘景福,杜小旺.纳米脂质体复合物-包封多酸化合物的合成,表征和生物活性研究[J].中国化学,2005,23(10):1397-1399. |
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| 作者姓名： | 杨勇 王晓红 李斌 刘景福 杜小旺 |
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| 作者单位： | [1]Department of Chemistry, Chongqing Normal University, Chongqing 400047, China [2]Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China （No. 20171011）, Chongqing Municipal Education Commision （No. kj05805）, and Chongqing Normal University （Nos. 05XSY001 and 05XLZ001）.Acknowledgements The authors are grateful to Liansheng S0NG and Gengyue ZHANG of Jilin Province Tumor Hospital, Changchun, for assaying the antitumoral activity. |
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| 摘 要： | The polyoxometalate K6HCoW11O39（CpTi）] （abbreviated as CoW11CpTi, Cp=η^5-C5H5） loaded nanosize-liposome complex has been prepared and structurally characterized by elemental analysis, IR and UV spectra. The particle size of the complex was distributed in the range of 100-250 nm with the average diameter of 132.6 nm. The result showed that the polyoxometalate retained the parent structure after being encapsulated by liposome and liposomal encapsulation increased the antitumoral activity of the polyoxometalate.
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| 关 键 词： | 脂质体 复合物 结构表征 生物活性 合成 |
| 收稿时间： | 2004-11-30 |
| 修稿时间： | 2004-11-302005-06-02 |
Synthesis, Characterization and the Biological Activity of a Polyoxometalate-loaded Nanosize-liposome Complex |
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| Yang Yong;Wang XiaoGong;Xu Gong;Chen Xin;Liang GuoMing;Gou Jin;Li Bin;Liu JingFu;Du XiaoWang.Synthesis, Characterization and the Biological Activity of a Polyoxometalate-loaded Nanosize-liposome Complex[J].Chinese Journal of Chemistry,2005,23(10):1397-1399. |
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| Authors: | Yang Yong;Wang XiaoGong;Xu Gong;Chen Xin;Liang GuoMing;Gou Jin;Li Bin;Liu JingFu;Du XiaoWang |
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| Abstract: | The polyoxometalate K6HCoW11O39(CpTi)] (abbreviated as CoW11CpTi, Cp=η5‐C5H5) loaded nanosize‐liposome complex has been prepared and structurally characterized by elemental analysis, IR and UV spectra. The particle size of the complex was distributed in the range of 100–250 nm with the average diameter of 132.6 nm. The result showed that the polyoxometalate retained the parent structure after being encapsulated by liposome and liposomal encapsulation increased the antitumoral activity of the polyoxometalate. |
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| Keywords: | plyoxometalate nanosize-liposome biological activity |
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