High-performance liquid chromatographic enantioseparation of aminonaphthol analogs on polysaccharide-based chiral stationary phases |
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| Authors: | Istvá n Ilisz,Zoltá n Pataj,Ró bert Berkecz,Istvá n Szatmá ri,Ferenc Fü lö p,Antal Pé ter |
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| Affiliation: | 1. Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary;2. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary |
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| Abstract: | High-performance liquid chromatographic methods were developed for the separation of the enantiomers of five new aminonaphthol analogs possessing two chiral centers. The direct separations were performed on chiral stationary phases containing either amylose-tris-3,5-dimethylphenyl carbamate (Kromasil® AmyCoat™ column) or cellulose-tris-3,5-dimethylphenyl carbamate (Kromasil® CelluCoat™ column) as chiral selector. The experimental data are utilized to discuss the effects of the mobile phase composition, the nature of the alcoholic modifier and the specific structural features of the analytes on the retention and separation. The elution sequence was determined in all cases; no general regularities could be established. |
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| Keywords: | Column liquid chromatography Enantiomer separation Aminonaphthol analogs AmyCoat&trade column CelluCoat&trade column |
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