Optimization of simulated moving bed chromatography with fractionation and feedback: Part I. Fractionation of one outlet |
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Authors: | Suzhou Li Yoshiaki Kawajiri Jörg Raisch Andreas Seidel-Morgenstern |
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Institution: | 1. Max-Planck-Institut für Dynamik komplexer technischer Systeme, Sandtorstraße 1, D-39106 Magdeburg, Germany;2. School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332, USA;3. Fachgebiet Regelungssysteme, Technische Universität Berlin, Einsteinufer 17, D-10587 Berlin, Germany;4. Lehrstuhl für Chemische Verfahrenstechnik, Otto-von-Guericke Universität, Universitätsplatz 2, D-39106 Magdeburg, Germany |
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Abstract: | A novel modification of simulated moving bed (SMB) technology, referred to as fractionation and feedback SMB (FF-SMB), has been introduced recently. This concept is based on fractionating one or both outlet streams and feeding the off-spec fractions back into the unit alternatingly with the original feed mixture. In this paper, the optimization problem of FF-SMB realizing one outlet fractionation is considered. A mathematical optimization framework based on a detailed process model is presented which allows to evaluate quantitatively the potential of this operating scheme. Detailed optimization studies have been carried out for a difficult separation characterized by small selectivity and low column efficiency. The results reveal that the proposed fractionation and feedback regime can be significantly superior to the classical SMB chromatography, in terms of both feed throughput and desorbent consumption. The effect of the feeding sequence on the performance of FF-SMB is also examined. |
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Keywords: | Simulated moving bed chromatography SMB Fractionation Feedback FF-SMB Optimization |
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