Determination of methyl nicotinate in pharmaceutical creams by high-performance thin-layer chromatography |
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| Authors: | B. De Spiegeleer W. Van den Bossche P. De Moerloose H. Stevens |
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| Affiliation: | (1) Department of Pharmaceutical Chemistry and Drug Quality Control, State University of Ghent, Harelbekestraat 72, B-9000 Gent, (Belgium);(2) Department of Mathematical Statistics, State University of Ghent, Krijgslaan 281 (S9), B-9000 Gent, (Belgium) |
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| Abstract: | ![]()
Summary A rapid, simple and specific high-performance, thin-layer chromatographic, photodensitometric method is described for the quantitative determination of methyl nicotinate. The HPTLC plates, coated with silica gel, are developed with a mobile phase which allows the separation of several active components in pharmaceutical creams. After quantitation of methyl nicotinate, a second solvent can be used for the identification of the cream base excipients. |
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| Keywords: | High-Performance TLC Pharmaceutical creams Methyl nicotinate Quantitation |
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