A platinum Chugaev carbene complex as a potent anticancer agent |
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| Authors: | Alves Georges Morel Laurent El-Ghozzi Malika Avignant Daniel Legeret Bertrand Nauton Lionel Cisnetti Federico Gautier Arnaud |
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| Institution: | CNRS, UMR 6247, GReD Laboratory, 24 Ave des Landais, F-63177, Aubière, France. |
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| Abstract: | A platinum Chugaev complex was synthesised and fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. This cis bis acyclic diamino carbene complex acts as a cytotoxic compound and behaves as a cisplatin equivalent by interacting with supercoiled DNA and thiols. Stability of the ligand is also discussed. |
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