Ammonium chloride catalyzed one-pot synthesis of imidazo[1,2-a]pyridines |
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Authors: | Ahmad Shaabani Fahimeh Rezazadeh Ebrahim Soleimani |
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Institution: | (1) Department of Chemistry, Shahid Beheshti University, Tehran, Iran |
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Abstract: | Ammonium chloride as a very inexpensive and readily available reagent efficiently catalyzes one-pot, three-component Groebke condensation reactions of aldehydes, isocyanides, and 2-aminopyridines or 2-aminopyrimidines in methanol to afford the corresponding
imidazo1,2-a]pyridines in high yields at room temperature.
Correspondence: Ahmad Shaabani, Department of Chemistry, Shahid Beheshti University, PO Box 19396-4716, Tehran, Iran. |
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Keywords: | Imidazo[1 2-a]pyridine Ammonium chloride Three-component reaction Isocyanide |
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