Performance of ICP-MS with Hexapole Collision Cell and Application for Determination of Trace Elements in Bio-Assays |
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Authors: | Sergei F Boulyga Hans-Joachim Dietze J Sabine Becker |
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Institution: | (1) Central Department for Analytical Chemistry, Research Center Jülich, D-52425 Jülich, Germany, DE;(2) Radiation Physics and Chemistry Problems Institute, 220109 Sosny, Minsk, Belarus, BY |
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Abstract: | The application of a hexapole collision cell in quadrupole based inductively coupled plasma mass spectrometry (HEX-ICP-QMS)
was studied systematically in order to characterize the performance of this approach for multielement analysis. Additionally,
the performance of different solution introduction systems was studied for use with HEX-ICP-QMS (Platform, Micromass Ltd.,
Manchester, UK) and the developed methods were applied in the multielement analysis of biological tissue. A significant improvement
in detection limits was achieved for ions affected by interferences with argon ions and argon-based molecular ions due to
the removal of Ar+ and ArX+ ions (X = H, C, N, O, Ar) as well as for heavy elements (m > 100 u) due to better ion transmission through the hexapole ion
guide. Metal oxide ion formation was reduced by up to ten times by the application of hexapole bias potential. Accuracy of
the HEX-ICP-QMS measurements was assessed by analyzing standard reference material SRM 1566a Oyster Tissue and comparison
with neutron activation analysis. Good agreement of measured trace element concentrations with certified values was found
for most elements.
Received December 7, 2000. Revision April 3, 2001. |
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Keywords: | : Inductively coupled plasma mass spectrometry hexapole collision cell trace analysis biological tissue |
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