Influence of photon energy on the efficiency of photochemotherapy |
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Authors: | M P Samtsov E S Voropay K N Kaplevsky D G Melnikau L S Lyashenko and Yu P Istomin |
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Institution: | (1) Department of Physics, Harbin Institute of Technology, P.O. Box 3025, 2 Yikuang Street, Nangang District, Science and Technology Park, Harbin, 150001, China;(2) Department of Stomatology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, China; |
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Abstract: | It is found that when indotricarbocyanine dye in HeLa cells is exposed to photons with different energies the efficiency of
cell damage is wavelength independent provided the photosensitizer absorbs the same number of photons per unit time. In vivo
animal experiments with two strains of tumor show that when the wavelength of the irradiating light is increased (668, 740,
and 780 nm) and the number of photons absorbed per unit time per unit volume of the tumors is held constant, the damage depth
increases by a factor of 1.5 and 3, respectively. The observed changes are related both to differences in the in vivo tissue
optical transmission with increasing wavelength and an increased local concentration of oxygen owing to photodissociation
of oxyhemoglobin. |
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