Clitidine,a new toxic pyridine nucleoside from clitocybe acromelalga |
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Authors: | K Konno K Hayano H Shirahama H Saito T Matsumoto |
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Institution: | Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060, Japan |
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Abstract: | From a poisonous mushroom, Clitocybe acromelalga, a new nucleoside clitidine (1) was isolated as a toxic principle. The structure was deduced to be 1 from spectral data and chemical degradation studies. Synthesis of 1 through condensation of methyl 4-aminonicotinate with 3, 5-di-O-benzoyl-D-ribofuranosyl chloride confirmed the structure, including absolute configuration. |
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