12-Acylindolo[1,2-c]quinazolines by palladium-catalyzed cyclocarbonylation of o-alkynyltrifluoroacetanilides |
| |
| Authors: | Battistuzzi Gianfranco Cacchi Sandro Fabrizi Giancarlo Marinelli Fabio Parisi Luca M |
| |
| Institution: | Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi La Sapienza, P.le A. Moro 5, 00185 Rome, Italy. |
| |
| Abstract: | 6-Trifluoromethyl-12-acylindolo1,2-c]quinazolines are prepared in high yield through the palladium-catalyzed reaction of bis(o-trifluoroacetamidophenyl)acetylene with aryl or vinyl halides and triflates. The reaction, which tolerates a variety of important functional groups, probably involves the formation of a 3-acyl-2-(o-trifluoroacetamidophenyl)indole intermediate, followed by its cyclization to the indoloquinazoline product. reaction: see text] |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
