In vitro Degradation and Biocompatibility of Ca-P Coated Magnesium Alloy |
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Authors: | XIAO Xing ZHU Qing-san SU Ying-chao LI Guang-yu |
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Institution: | 1. The First Hospital of Jilin University, Changchun 130021, P. R. China;
2. College of Materials Science and Engineering, Jilin University, Changchun 130022, P. R. China |
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Abstract: | Calcium-phosphate compounds(Ca-P) coating was prepared on an Mg-Al alloy(AZ60). Biodegradation of Ca-P coated magnesium alloy was evaluated in simulated body fluid(SBF) by examining the changes in magnesium ion concentration and pH value, which indicated that the Ca-P coating on magnesium alloy strongly affected the corrosion of magnesium alloy. Osteoblast MC3T3-E1 cells were utilized to investigate the cellular cytocompatibility. The cytocompatibility was measured by carrying out a series of tests, such as cholecystokinin-octapeptide(CCK-8) test, alkaline phosphatase activity(ALP) test, cellular morphology of hematoxylin-eosin(HE) staining and the induction of apoptosis. It was found that the cell function showed better in the Ca-P coated Mg-alloy extract than in the uncoated magnesium alloy extract. In summary, the results indicate that the Ca-P coating can improve the corrosion resistance of magnesium alloy and elevate cellular proliferation and differentiation of osteoblast MC3T3-E1 cells. |
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Keywords: | Ca-P coating Magnesium alloy In vitro |
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