4-Hydroxy-2-quinolones 144. Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid and their diuretic properties |
| |
| Authors: | I. V. Ukrainets I. A. Tugaibei N. L. Bereznyakova V. N. Kravchenko A. V. Turov |
| |
| Affiliation: | (1) National Pharmaceutical University, Kharkiv, 61002, Ukraine;(2) Kharkiv Medicinal Academy of Postgraduate Education, Kharkiv, 61176, Ukraine;(3) Taras Shevchenko National University, Kiev, 01033, Ukraine |
| |
| Abstract: | Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid were prepared with a view to establishing a structure-biological activity relationship. A comparative analysis has been made of their diuretic properties and those of the structurally similar 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 718–729, May, 2008. |
| |
| Keywords: | amides 2-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylic acids tricarbonylmethane heterocyclic derivatives diuretic activity X-ray structural analysis |
| 本文献已被 SpringerLink 等数据库收录！ |
|
