Synthesis of Substituted 2‐Amino‐1,3‐oxazoles via Copper‐Catalyzed Oxidative Cyclization of Enamines and N,N‐Dialkyl Formamides |
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Abstract: | A facile synthesis of 2‐amino‐1,3‐oxazoles via CuI‐catalyzed oxidative cyclization of enamines and N ,N ‐dialkyl formamides has been developed. The reaction proceeds through an oxidative C?N bond formation, followed by an intramolecular C(sp2)?H bond functionalization/C?O cyclization in one pot. This protocol provides direct access to useful 2‐amino‐1,3‐oxazoles and features protecting‐group‐free nitrogen sources, readily available starting materials, a broad substrate scope and mild reaction conditions. |
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Keywords: | 2-amino-1 3-oxazoles C-H activation copper cyclization enamines |
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