Synthesis of [18F]Fluoroarenes by Nucleophilic Radiofluorination of N‐Arylsydnones

A practical method for radiofluorination of anilines with [¹⁸F]fluoride via N ‐arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective ¹⁸F‐labeling to prepare [¹⁸F]fluoroarenes. The value of this methodology is further highlighted by successful application to prepare an ¹⁸F‐labeled neuropeptide.