Convergent synthesis of oligomers of triazole-linked DNA analogue (DNA) in solution phase |
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| Authors: | Tomoko Fujino |
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| Affiliation: | Department of Chemistry, Tohoku University, Aoba-ku, Sendai 980-8578, Japan |
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| Abstract: | ![]()
A convergent route for the solution-phase synthesis of oligomeric triazole-linked analogues of DNA (TLDNA) has been developed. A one-pot procedure for desilylation of masked acetylene and the ensuing copper-catalyzed Huisgen coupling reaction between oligomers allowed the solution-phase synthesis of 7-mer and 8-mer TLDNA in good yield. |
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| Keywords: | Click chemistry Artificial oligonucleotide Convergent synthesis Solution-phase synthesis |
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