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Formal total synthesis of borrelidin: synthesis of C1-C11 fragment via desymmetrization strategy |
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| Authors: | JS Yadav Padmavani Bezawada Venugopal Chenna |
| Institution: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | A stereoselective formal total synthesis of borrelidin is described. The synthetic strategy for synthesis of C1-C11 fragment features desymmetrization of Diels-Alder adduct, Sharpless asymmetric epoxidation, regioselective opening of chiral epoxide, and alkylation using Evans chiral auxiliary. |
| Keywords: | Borrelidin Desymmetrization Sharpless asymmetric epoxidation Evan&rsquo s chiral auxiliary |
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