New phenanthrenes from Trigonostemon lii Y.T. Chang |
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Authors: | Xu-Jia Hu Yue-Hu Wang Hong-Ping He Hai-Yang Liu Hua Xie Xiao-Jiang Hao |
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Affiliation: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China b Yunnan Institute for Food and Drug Control, Kunming 650011, PR China c Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, PR China d Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, PR China |
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Abstract: | Three new phenanthrenes, thrigonosomone A (1), 6,9-O-dedimethyltrigonostemone (2), and thrigonosomone B (3) were isolated from Trigonostemon lii. Their structures were elucidated by spectroscopic methods. Thrigonosomone A (1) possessed a novel seven-membered cyclic anhydride moiety, and its relative configuration was determined by chemical computation and ROESY experiment. The cytotoxicity of compounds 1-3 was also evaluated. |
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