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Stereoselective synthesis of the cytotoxic macrolide aspergillide B |
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| Authors: | Santiago Dí az-Oltra,Marí a N. Kneeteman,Miguel Carda |
| Affiliation: | a Depart. de Q. Inorgánica y Orgánica, Univ. Jaume I, Castellón, E-12080 Castellón, Spain b Depart. de Química, Fac. Ing. Química, Univ. del Litoral, Santa Fe, Argentina c Depart. de Q. Orgánica, Univ. de Valencia, E-46100 Burjassot, Valencia, Spain |
| Abstract: | A total, stereoselective synthesis of the cytotoxic macrolide aspergillide B has been performed. A cross metathesis and a C-glycosidation via a Mukaiyama-type aldol reaction were key features of the synthesis. The macrocyclic lactone ring was created by means of the Yamaguchi procedure. |
| Keywords: | Macrolides Aspergillides Mukaiyama C-glycosidation Cross metathesis Yamaguchi macrolactonization Brown asymmetric allylation |
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