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Highly efficient prolinamide-based organocatalysts for the direct asymmetric aldol reaction in brine |
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| Authors: | Ya-Ning Jia Xiao Ma Chao-Shan Da |
| Affiliation: | a Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China |
| Abstract: | Four prolinamide-based organocatalysts were readily synthesized and applied to the direct asymmetric aldol reactions of ketones and aromatic aldehydes in brine. When 2,4-dinitrophenol (DNP) was used as an acidic additive, 1 mol % low loading of 2b afforded aldol products with excellent diastereoselectivity of up to 98/2 dr and high enantioselectivity of up to 97% ee. |
| Keywords: | Asymmetric catalysis Organocatalysis Direct aldol reaction Low loading of catalyst Brine |
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