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Synthesis and structure of new 1,3,5-triazine-pyrazole derivatives
Authors:Svetlana N Mikhaylichenko  Saurabh M Patel  Aleksey A Chesnyuk
Institution:a Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada M1C 1A4
b Department of Organic Chemistry, Kuban State Agricultural University, Krasnodar 350044, Russian Federation
Abstract:We have studied the reaction of methylenedicarbonyl compounds with 4,6-disubstituted 2-hydrazinyl-1,3,5-triazine in order to obtain novel coupled biheterocyclic aromatic systems with potential bioactivity. Reaction conditions were studied and optimized, and a series of 4,6-disubstituted 2-(1H-pyrazolyl)-1,3,5-triazines were obtained with good yield.
Keywords:Cyclization  Hydrazinyl-triazines  1  3-Dicarbonyl compounds  Coupled 1  3  5-triazine-pyrazole derivatives  Synthesis and structure
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