|
|||||
|
|
Fractal dimension of the choriocarcinoma cell invasion front |
|
| Authors: | H Ahammer Ch Helige U Weiss-Fuchs |
| Institution: | a Institute of Biophysics, Center of Physiological Medicine, Medical University of Graz, Harrachgasse 21, A-8010 Graz, Austria b Institute of Cell Biology, Histology and Embryology, Center of Molecular Medicine, Medical University of Graz, A-8010 Graz, Austria c ARC Seibersdorf Research GmbH, Business Field Toxicology, A-2444 Seibersdorf, Austria |
| Abstract: | The Minkowski dimension was calculated for the determination of the invasiveness of cancer cells, which were brought in close contact (confronted) to host tissues and cultivated in vitro. The confrontation cultures were histologically sectioned and stained immunohistochemically. Digital images of these sections were segmented, processed and the specimens’ boundaries were investigated. The invasion front was treated as a fractal. The value of the Minkowski dimension increased with increased invasiveness of the cells. The Minkowski dimension could be used as a quantitative measure for cancer diagnosis. |
| Keywords: | Fractal dimension Invasion front Cancer Choriocarcinoma |
| 本文献已被 ScienceDirect 等数据库收录！ | |