纤维素三苯基氨基甲酸酯涂敷型固定相的制备及其对奥美拉唑的拆分 |
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引用本文: | 危凤,杨亦文,任其龙,吴平东.纤维素三苯基氨基甲酸酯涂敷型固定相的制备及其对奥美拉唑的拆分[J].分析化学,2003,31(6):735-738. |
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作者姓名: | 危凤 杨亦文 任其龙 吴平东 |
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作者单位: | 浙江大学二次资源化工国家专业实验室,杭州,310027 |
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基金项目: | 浙江省自然科学基金资助项目 (No .2 0 10 92 ) |
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摘 要: | 制备了纤维素三苯基氨基甲酸酯涂敷在自制的大孔氨丙基硅胶上的手性固定相,并对奥美拉唑进行了手性拆分。考察了流动相组成和流速对拆分效果的影响,发现用乙醇/正已烷作为流动相,手性物的分离度优于文献报道的异丙醇/正已烷流动相体系,适宜的流动相配比为乙醇/正已烷(40/60,V/V)。分离度随流动相中乙醇含量和流动相流速的增加而减小。
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关 键 词: | 纤维素三苯基氨基甲酸酯 涂敷型固定相 制备 奥美拉唑 手性拆分 胃溃疡治疗药物 |
Preparation of Coated Cellulose Triphenylcarbamate Chiral Stationary Phase for the Resolution of Omeprazole |
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Abstract: | Enantiomers of omeprazole were separated on a chiral stationary phase prepared by coating cellulose triphenylcarbamate on a large pore aminopropyl silica gel. The effect of composition and flow rate of mobile phase on the resolution was investigated. It was found that the resolution by ethanol/hexane is much better than that by 2 propanol/hexane. The best composition of mobile phase is ethanol/hexane=40/60( V/V ). As the flow rate and the ethanol concentration of mobile phase increase, the resolution decreases. |
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Keywords: | Chiral resolution chiral stationary phase omeprazole hight performance liquid chromatography |
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