Synthesis and properties of 2-substituted 5-chloro-1,3-oxazole-4-carboxamides |
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Authors: | A. N. Kornienko S. G. Pil’o V. M. Prokopenko V. S. Brovarets |
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Affiliation: | 1. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 1, Kyiv, 02660, Ukraine
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Abstract: | Chlorination of 2-aryl-5-benzylsulfanyl-1,3-oxazole-4-carbonitrile in aqueous acetic acid at 50–60°C afforded new 2-aryl-5-chloro-1,3-oxazole-4-carboxamides. The reactivity of the chlorine atom with respect to the N-, O-, and S-nucleophiles was investigated. |
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