Total synthesis of gambierol |
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| Authors: | Fuwa Haruhiko Sasaki Makoto Satake Masayuki Tachibana Kazuo |
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| Institution: | Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan. |
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| Abstract: | structure: see text] The first total synthesis of gambierol, a marine polycyclic ether toxin, has been achieved. The synthesis features the Pd(PPh3)4/CuCl/LiCl-promoted Stille coupling for the stereoselective construction of the sensitive triene side chain that includes a conjugated (Z,Z)-diene moiety. |
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