|
|||||
|
|
Synthesis of (3S,4R)-bengamide E |
|
| Authors: | Qi Jun Liu Hong Li a Guangzhou Institutes of Biomedicine Health Chinese Academy of Sciences Guangzhou China b Graduate School of Chinese Academy of Sciences Beijing China c College of Pharmaceutical Sciences Nanjing University of Technology Nanjing China |
| Institution: | a Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China;b Graduate School of Chinese Academy of Sciences, Beijing 100039, China;c College of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing 210009, China |
| Abstract: | (3S,4R)-Bengamide E（2） was synthesized starting from D-glucono-δ-lactone（3） and the key deoxygenation step from 13 to 15 was achieved by the application of NaBH3CN and ZnI2.Compared with natural bengamide E（1）,the synthetic compound（35,4R）-bengamide E（2） was inactive against the cell growth of HUVEC and cancer cells.These data represent the significance of the stereochemistry at C-3 and C-4 of bengamides for structural recognition and binding with the target（s）. |
| Keywords: | (3S 4R)-Bengamide E Stereocenter Deoxygenation |
| 本文献已被 CNKI 等数据库收录！ | |
| 点击此处可从《中国化学快报》浏览原始摘要信息 | |
| 点击此处可从《中国化学快报》下载免费的PDF全文 | |