Preparation of a PTE simulacrum based on surface molecular imprinting

Firstly,we synthesized N-methacryloyl-histidine monomer and N-methacryloyl-histidine-Cu~(2+) complex(MAH-Cu~(2+)).Then the molecular imprinting polymers(MIP) has been prepared by surface grafting on uniform polystyrene(PS) core using reversible addition-fragmentation transfer polymerization(RAFT) with MAH-Cu~(2+) as the functional monomer,methyl paraoxon as the template to simulate phosphodiesterase(PTE).Finally,we have investigated the catalytic hydrolytic activities of MIP and non-imprinting polymers(NIP)...