Identification of the metabolites of biologically active xanthones isolated from Halenia elliptica D.Don by high performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry |
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| Authors: | Ru Fenga Jian Gong Shia Xiao Wei Liub Chun Tao Chec John H.K.Yeungd Yan Wang a Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China b |
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| Affiliation: | Ru Feng~a,Jian Gong Shi~a,Xiao Wei Liu~b,Chun Tao Che~c,John H.K.Yeung~d,Yan Wang~(a,*) a Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China b Department of Ophthalmology,Peking Union Medical College Hospital,Beijing 100730,China c School of Chinese Medicine,The Chinese University of Hong Kong,Shatin,NT,Hong Kong SAR,China d Department of Pharmacology,Faculty of Medicine,The C... |
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| Abstract: | Metabolism study has been carried out on 1-hydroxy-2,3,5-trimethoxyxanthone(HM-1) and 1-hydroxy-2,3,4,7- tetramethoxyxanthone(HM-2),which are two biologically active ingredients isolated from the Tibetan herb,Halenia elliptica D.Don.,in rat liver microsomes in vitro.A method of high performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry(LCMS~n-ESI-IT-TOF) was applied to analyze metabolites of HM-1 and HM-2 on line,and five metabolites were identified containing 1,5-dihydroxy-... |
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| Keywords: | Halenia elliptica Xanthone Biotransformation LCMS~n-ESI-IT-TOF Metabolite identification |
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