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Determination of metoprolol in rabbit blood using capillary electrophoresis with laser-induced fluorescence detection |
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| Authors: | Yu Yun Chen Wei Ping Yangb Zhu Jun Zhangc a College of Environmental Science Engineering Chang'an University Xi'an China b Education School of Nationalities Shaanxi Normal University Xi'an China c |
| Affiliation: | a College of Environmental Science and Engineering, Chang'an University, Xi'an 710054, China;b Education School of Nationalities, Shaanxi Normal University, Xi'an 710062, China;c Department of Chemistry, Shaanxi Normal University, Xi'an 710062, China |
| Abstract: | This work described a sensitive method for determination of metoprolol in rabbit plasma.The method involved purification by ultrafiltration,derivatization with fluorescein isothiocyanate,determination by capillary electrophoresis(CE) coupled with laser-induced fluorescence(LIF) detector.Other components in plasma including a variety of amino acids and proteins did not interfere with the determination of metoprolol in experimental condition.The assay had a wide range(2.0-500 ng/mL) of linearity and a detecti... |
| Keywords: | Capillary electrophoresis Metoprolol Laser-induced fluorescence Ultrafiltration Pharmacokinetic |
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