Synthesis,Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin |
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| Authors: | Stephen Lo Euphemia Leung Bruno Fedrizzi David Barker |
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| Affiliation: | 1.School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand; (S.L.); (B.F.);2.Auckland Cancer Society Research Centre, University of Auckland, Auckland 1023, New Zealand;3.MacDiarmid Institute for Advanced Materials and Nanotechnology, Wellington 6012, New Zealand |
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| Abstract: | Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5-O-acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity against the HCT116 colon cancer and MDA-MB-231 breast cancer cell lines; and their radical scavenging activity against the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical species. Four derivatives were found to have improved the antiproliferative activity compared to quercetin whilst retaining radical scavenging activity. |
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| Keywords: | quercetin antiproliferative colon cancer breast cancer radical scavenging |
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