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Assessing the antimicrobial activity of zinc oxide thin films using disk diffusion and biofilm reactor |
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| Authors: | Shaun D. Gittard John R. Perfect Wei Wei Roger J. Narayan |
| Affiliation: | a Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States b Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, United States c Department of Medicine, Division of Infectious Diseases, Duke University, Durham, NC, United States d Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, United States e Department of Materials Science Engineering, North Carolina State University, Raleigh, NC, United States |
| Abstract: | The electronic and chemical properties of semiconductor materials may be useful in preventing growth of microorganisms. In this article, in vitro methods for assessing microbial growth on semiconductor materials will be presented. The structural and biological properties of silicon wafers coated with zinc oxide thin films were evaluated using atomic force microscopy, X-ray photoelectron spectroscopy, and MTT viability assay. The antimicrobial properties of zinc oxide thin films were established using disk diffusion and CDC Biofilm Reactor studies. Our results suggest that zinc oxide and other semiconductor materials may play a leading role in providing antimicrobial functionality to the next-generation medical devices. |
| Keywords: | Antimicrobial materials Pulsed laser deposition Zinc oxide |
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