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The synthesis of 4,4′-arylmethylene-bis(3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-ol) in aqueous media without catalyst |
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| Authors: | Chang-Sheng Yao Chen-Xia Yu Shu-Jiang Tu Da-Qing Shi Xiang-Shan Wang You-Quan Zhu |
| Affiliation: | a Department of Chemistry, Xuzhou Normal University, Xuzhou 221116, People's Republic of China b Key Laboratory of Biotechnology for Medical Plants of Jiangsu Province, Xuzhou 221116, People's Republic of China c State Key Laboratory of Element-Organic Chemistry, Institute of Element-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China |
| Abstract: | The synthesis of 4,4′-arylmethylene-bis(3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-ol) was performed effectively in aqueous media without catalyst by the reaction of aryl aldehydes and 1-phenyl-3-trifluoromethylpyrazol-5-one. All of the compounds obtained were characterized by elemental analysis, FTIR and 1H NMR. The structure of compound 3g was further confirmed by the X-ray single crystal diffraction. The method has the advantages of mild condition, without any catalyst, high yields and environmentally benign procedure. |
| Keywords: | Environment friendly Aqueous media Catalyst 1-Phenyl-3-trifluoromethylpyrazol-5-one 4,4&prime -Arylmethylene-bis(3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5-ol) |
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