Preparative-scale synthesis of 3,3,3-trifluoropropene oxide |
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| Authors: | P Veeraraghavan Ramachandran Kamlesh J Padiya |
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| Institution: | Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907-2084, United States |
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| Abstract: | Bromination of 3,3,3-trifluoropropene in 20% oleum, followed by treatment with acetic acid furnishes 2-bromo-3,3,3-trifluoropropyl acetate in quantitative yield, which upon acid hydrolysis and cyclization with alkali affords 3,3,3-trifluoropropene oxide (TFPO) in 63% overall yield. |
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| Keywords: | 3 3 3-Trifluoropropene 3 3 3-Trifluoropropene oxide Oxirane Silver acetate Bromination Bromoacetoxylation |
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