Application
of microcalorimetry to the formulation study |
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| Authors: | K Terada T Masuda Y Yoshihashi E Yonemochi |
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| Institution: | (1) Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Toho University, Chiba Japan, 274-8510, 2-2-1 Miyama Funabashi |
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| Abstract: | Isothermal
microcalorimetry was used to evaluate excipient compatibility of solid dosage
form. Oxybutynin hydrochloride and cefaclor were used as model drugs for compatibility
test with excipients. The calorimetric data for compatibility test were compared
with those of HPLC data. Evaluation of compatibility between drug and excipient
of solid dosage form might be possible to use isothermal microcalorimetry
instead of conventional method. By using microcalorimetric method, the evaluation
of the compatibility between drug and excipient could be successfully performed
with a simple operation in a short time. The application of the isothermal
microcalorimetry would be useful for the screening test of the drug compatibility
with excipients. |
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| Keywords: | cefaclor drug-excipient compatibility formulation isothermal microcalorimetry oxybutynin hydrochloride |
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