| 1,4-苯并二(口恶)烷类新木脂素Eusiderin G的全合成 |
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| 引用本文： | 汪秋安,孙朝旭,陈清奇. 1,4-苯并二(口恶)烷类新木脂素Eusiderin G的全合成[J]. 有机化学, 2000, 20(6) |
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| 作者姓名： | 汪秋安 孙朝旭 陈清奇 |
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| 作者单位： | 1. 湖南大学化学化工学院,长沙,410082
2. Department of Chemistry,University of British Columbia,Vancouver,BC.Vancouver,BC.V6T 1Z1,Canada |
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| 摘 要： | 以没食子酸甲酯为原料,经过6步反应(总产率为24％),对 1,4-苯并二噁烷类新木脂素天然产物Eusiderin G进行了全合成。合成反应的关键步骤是在强酸性离子交换树脂催化下,分子内的醇羟基与酚羟基之间发生脱水反应,关环形成1,4-苯并二噁烷骨架化合物。该合成路线具有简便易行、产率较高、副反应少的特点,可适用于其它具有生理活性的1,4-苯二噁烷类化合物的合成。
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| 关 键 词： | 1 4-苯并二噁烷 新木脂素 Eusiderin G 全合成 |
A Facile Total Synthesis of 1,4-Benzodioxane Type Neolignans, Eusiderin G |
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| WANG Qiu-An,SUN Zhao-Xu,CHEN Qing-Qi. A Facile Total Synthesis of 1,4-Benzodioxane Type Neolignans, Eusiderin G[J]. Chinese Journal of Organic Chemistry, 2000, 20(6) |
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| Authors: | WANG Qiu-An SUN Zhao-Xu CHEN Qing-Qi |
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| Abstract: | An efficient transformation of methyl gallate to Eusiderin G7, a neolignan with 1,4- benzodioxane nuclei, in six steps with 24% overall yield is reported. This route is distinctly shorter, more economic and efficient than any of the previous approaches to the target reported in the literature. The key step is a cyclization of an dihydroxy intermediate 4 catalysted by a strong acid ion exchange resin to give 1,4- benzodioxane skeleton. |
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| Keywords: | 1 4- Benzodioxane Neolignans Eusiderin G Total Synthesis |
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