Palladium-catalyzed intermolecular coupling of aryl halides and amides |
| |
Authors: | Yin J Buchwald S L |
| |
Institution: | Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA. |
| |
Abstract: | formula: see text] The first general intermolecular C-N bond-forming reactions between aryl halides and amides were realized using a palladium catalyst with Xantphos as the ligand. Aryl triflates, carbamates, and sulfonamides are also viable substrates for the amidations, which proceed at 45-110 degrees C with 1-4 mol% of Pd catalyst in 66-99% yields and exhibit good functional group compatibility. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|