首页 | 本学科首页   官方微博 | 高级检索  
     


Fast supercritical fluid chromatography of polymers using packed capillary columns
Authors:N. Wu  R. Yee  M. L. Lee
Affiliation:(1) Department of Chemistry and Biochemistry, Brigham Young University, 84602-5700 Provo, UT, USA;(2) ALZA Corporation, Mountain View, 94043-1218, CA, USA;(3) Present address: Merck Research Laboratories, 07065 Rahway, NJ, USA
Abstract:Summary Fast separations of perfluorinated polyethers and polymethylsiloxanes that are composed of 50–80 oligomers were demonstrated in packed capillary column supercritical fluid chromatography (SFC) using a carbon dioxide mobile phase. Separations were accomplished within 10 min using a 13 cm×250 μm i.d. column packed with 2 μm porous octadecyl bonded silica (ODS) particles. Effects of particle diameter of the packing material and pressure programming on separation were investigated, and packed column SFC was compared with open tubular column SFC. Results show that as the particle diameter was decreased from 5 to 3 to 2 μm and the column length was reduced from 85 to 43 to 13 cm, the separation time could be reduced from 70 to 20 to 10 min while still maintaining similar separation (resolution). Short columns packed with small porous particles are very suitable for fast SFC separations of polymers.
Keywords:Supercritical fluid chromatography  Packed capillary  Perfluorinated polyethers  Polymethylsiloxane  Carbon dioxide  Fast separations
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号